A 1m pilot strategy hopes to reduce the risk of women developing breast cancer by helping them lose weight and become more active.
Women over 50 attending screening will be asked to had participated in the trial ActWell in Aberdeen, Dundee, Edinburgh and Glasgow.
The Scottish government-funded research will be led by the University of Dundee and supported by Breast Cancer Now.
If successful, the strategy could be rolled out to other NHS Boards.
Breast Cancer Now is seeking 24 volunteers to teach as lifestyle tutors to support the trial.
They will work with women to help them stimulate long-lasting changes focused around physical activity, diet and weight.
About 4,600 women in Scotland are diagnosed with breast cancer each year and about 1,000 lose their life to the disease annually.
Experts estimate that 38% of breast cancer examples in post-menopausal women could be prevented by lifestyle changes linked to inactivity, poor diet, booze intake and weight.
Health Secretary Shona Robison said: “Prevention is a key part of our cancer strategy.
“We know things like weight, diet and ” activities can all significantly is contributing to your risk of developing cancer.
“With breast cancer risk in women over 50, the link is particularly pronounced.
“By recruiting volunteers to work as lifestyle tutors, this strategy will test whether we can reduce those risks and save women and their families from having to face up to a cancer diagnosis.”
Mary Allison, administrator of Breast Cancer Now Scotland, said: “The trial has the potential to have a significant impact on reducing the risk of breast cancer in Scottish women.
“Recruiting lifestyle tutors will form an integral part to the success of ActWell. We’re looking for people with an interest in health and lifestyle.
“We want to attract those who are keen to make a difference to women’s lives.”
Annie Anderson, professor of public health nutrition at the University of Dundee and co-director of the Scottish Cancer Prevention Network, said: “An increased emphasis on prevention is vital if we are to combat breast cancer.
“Physical inactivity, diet, alcohol intake and body weight are all significant risk factors in developing the disease.
“With such studies we are looking to support women with ActWell lifestyle tutors and give them access to services that can help reduce these risks.
“This starts with a 30 -second conversation at the breast screening centre but it could have life-changing effects.
“Our pilot study showed considerable benefits for women aged over 50 which is extremely encouraging.”